Bing Yao, Ph.D.
bing.yao@emory.edu
Faculty Page | Google Scholar | X
I am an Associate Professor of Human Genetics, and my long-term research interests center on understanding the pivotal roles of epigenetic regulation in mammalian neurodevelopment and how dysregulation of these processes may contribute to neural pathology. I have a broad background in genetics, epigenetics, cell biology, biochemistry, molecular biology, and bioinformatics, and I work with multiple model systems. I have established a multifaceted research program addressing fundamental questions at different layers of neuroepigenetics.
Ongoing projects in my lab focus on:
i) canonical epigenetic mechanisms such as DNA modifications;
ii) a novel DNA-RNA hybrid structure termed R-loops; and
iii) a unique class of regulatory RNAs with circularized structures, known as circRNAs, which are considered broadly “epigenetic regulators” in a broad sense.
We aim to elucidate their coordinated functions in neurodevelopment and how their dysregulation may contribute to brain diseases such as Alzheimer’s disease (AD). Our work integrates multiple approaches, including genome-wide, high-throughput epigenomic and transcriptomic analysis, CRISPR-Cas9 gene editing, and cellular and molecular biology. We are also expanding into next-generation long-read sequencing, single-cell epigenomics, and spatial transcriptomics to enhance the resolution and depth of our studies. We have already established various disease mouse models, obtained human postmortem brain tissues, and developed human iPSC-derived 2D neurons and 3D “mini-brain” organoids to investigate these mechanisms both in vitro and in vivo.
Contact Information:
Bing Yao, Ph.D.
Associate Professor of Human Genetics
Emory University School of Medicine
Whitehead Research Building, Room 305A
615 Michael Street,
Atlanta, GA, 30322
Office: 404-727-1725
Lab: 404-778-8535
Web: http://www.yao-lab.org/
Email: bing.yao@emory.edu
bing.yao@emory.edu
Faculty Page | Google Scholar | X
I am an Associate Professor of Human Genetics, and my long-term research interests center on understanding the pivotal roles of epigenetic regulation in mammalian neurodevelopment and how dysregulation of these processes may contribute to neural pathology. I have a broad background in genetics, epigenetics, cell biology, biochemistry, molecular biology, and bioinformatics, and I work with multiple model systems. I have established a multifaceted research program addressing fundamental questions at different layers of neuroepigenetics.
Ongoing projects in my lab focus on:
i) canonical epigenetic mechanisms such as DNA modifications;
ii) a novel DNA-RNA hybrid structure termed R-loops; and
iii) a unique class of regulatory RNAs with circularized structures, known as circRNAs, which are considered broadly “epigenetic regulators” in a broad sense.
We aim to elucidate their coordinated functions in neurodevelopment and how their dysregulation may contribute to brain diseases such as Alzheimer’s disease (AD). Our work integrates multiple approaches, including genome-wide, high-throughput epigenomic and transcriptomic analysis, CRISPR-Cas9 gene editing, and cellular and molecular biology. We are also expanding into next-generation long-read sequencing, single-cell epigenomics, and spatial transcriptomics to enhance the resolution and depth of our studies. We have already established various disease mouse models, obtained human postmortem brain tissues, and developed human iPSC-derived 2D neurons and 3D “mini-brain” organoids to investigate these mechanisms both in vitro and in vivo.
Contact Information:
Bing Yao, Ph.D.
Associate Professor of Human Genetics
Emory University School of Medicine
Whitehead Research Building, Room 305A
615 Michael Street,
Atlanta, GA, 30322
Office: 404-727-1725
Lab: 404-778-8535
Web: http://www.yao-lab.org/
Email: bing.yao@emory.edu