Bing Yao, Ph.D.
bing.yao@emory.edu
Faculty Page | Google Scholar | X
I am an Associate Professor of Human Genetics and my long-term research interests are to understand the pivotal roles of epigenetic regulation in mammalian neurodevelopment, as well as how dysregulation of these processes may contribute to neural pathology. I have a broad background in genetics, epigenetics, cell biology, biochemistry, molecular biology, and bioinformatics using multiple model systems. I set up a multifaceted research program tackling fundamental questions at different layers of neuroepigenetics. The ongoing projects in my lab include i) canonical epigenetic mechanisms such as DNA modifications, ii) a novel DNA:RNA hybrid structure termed "R-loops," and iii) a unique class of regulatory RNAs with circularized structures termed circRNAs, which are considered as "epigenetic regulators" in a broad sense. We aim to elucidate their coordinative functions in neurodevelopment and how dysregulation of these processes may contribute to brain diseases such as Alzheimer's Disease (AD). Our work integrates multiple approaches, including genome-wide high-throughput epigenomic and transcriptomic analysis, CRISPR-Cas9 gene editing and engineering, and cellular and molecular biology. We are moving to include next-generation long-read sequencing, single-cell epigenomics and spatial transcriptomic techniques to enhance the resolution of our study. We already established various disease mouse models, obtained human postmortem brains, and developed human iPSC-derived 2D neurons and 3D mini-brain organoids to study these mechanisms in vitro and in vivo.
Contact Information:
Bing Yao, Ph.D.
Associate Professor of Human Genetics
Emory University School of Medicine
Whitehead Research Building, Room 305A
615 Michael Street,
Atlanta, GA, 30322
Office: 404-727-1725
Lab: 404-727-1837
Web: http://www.yao-lab.org/
Email: bing.yao@emory.edu
bing.yao@emory.edu
Faculty Page | Google Scholar | X
I am an Associate Professor of Human Genetics and my long-term research interests are to understand the pivotal roles of epigenetic regulation in mammalian neurodevelopment, as well as how dysregulation of these processes may contribute to neural pathology. I have a broad background in genetics, epigenetics, cell biology, biochemistry, molecular biology, and bioinformatics using multiple model systems. I set up a multifaceted research program tackling fundamental questions at different layers of neuroepigenetics. The ongoing projects in my lab include i) canonical epigenetic mechanisms such as DNA modifications, ii) a novel DNA:RNA hybrid structure termed "R-loops," and iii) a unique class of regulatory RNAs with circularized structures termed circRNAs, which are considered as "epigenetic regulators" in a broad sense. We aim to elucidate their coordinative functions in neurodevelopment and how dysregulation of these processes may contribute to brain diseases such as Alzheimer's Disease (AD). Our work integrates multiple approaches, including genome-wide high-throughput epigenomic and transcriptomic analysis, CRISPR-Cas9 gene editing and engineering, and cellular and molecular biology. We are moving to include next-generation long-read sequencing, single-cell epigenomics and spatial transcriptomic techniques to enhance the resolution of our study. We already established various disease mouse models, obtained human postmortem brains, and developed human iPSC-derived 2D neurons and 3D mini-brain organoids to study these mechanisms in vitro and in vivo.
Contact Information:
Bing Yao, Ph.D.
Associate Professor of Human Genetics
Emory University School of Medicine
Whitehead Research Building, Room 305A
615 Michael Street,
Atlanta, GA, 30322
Office: 404-727-1725
Lab: 404-727-1837
Web: http://www.yao-lab.org/
Email: bing.yao@emory.edu